Kainate receptor pharmacology and physiology

被引：20

作者：

Bleakman, D ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Lab, Lilly Corp Ctr, Indianapolis, IN 46285 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 56卷 / 7-8期

关键词：

glutamate receptors; antagonist; desensitization; agonist;

D O I：

10.1007/s000180050453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists. These compounds have allowed scientists to begin to probe the functional properties of these receptors in neurons and gain a better understanding of the role of these receptors in the nervous system.

引用

页码：558 / 566

页数：9

共 109 条

[1] THE PRIMARY AFFERENT DEPOLARIZING ACTION OF KAINATE IN THE RAT [J].

AGRAWAL, SG ;

EVANS, RH .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 87 (02) :345-355

[2] SELECTIVE DEPRESSION OF EXCITATORY AMINO-ACID INDUCED DEPOLARIZATIONS BY MAGNESIUM-IONS IN ISOLATED SPINAL-CORD PREPARATIONS [J].

AULT, B ;

EVANS, RH ;

FRANCIS, AA ;

OAKES, DJ ;

WATKINS, JC .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 307 (OCT) :413-428

[3]

BAHN S, 1994, J NEUROSCI, V14, P5525

[4] CLONING OF A NOVEL GLUTAMATE RECEPTOR SUBUNIT, GLUR5 - EXPRESSION IN THE NERVOUS-SYSTEM DURING DEVELOPMENT [J].

BETTLER, B ;

BOULTER, J ;

HERMANSBORGMEYER, I ;

OSHEAGREENFIELD, A ;

DENERIS, ES ;

MOLL, C ;

BORGMEYER, U ;

HOLLMANN, M ;

HEINEMANN, S .

NEURON, 1990, 5 (05) :583-595

[5] CLONING OF A PUTATIVE GLUTAMATE RECEPTOR - A LOW AFFINITY KAINATE-BINDING SUBUNIT [J].

BETTLER, B ;

EGEBJERG, J ;

SHARMA, G ;

PECHT, G ;

HERMANSBORGMEYER, I ;

MOLL, C ;

STEVENS, CF ;

HEINEMANN, S .

NEURON, 1992, 8 (02) :257-265

[6] A SINGLE AMINO-ACID DETERMINES THE SUBUNIT-SPECIFIC SPIDER TOXIN BLOCK OF ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONATE KAINATE RECEPTOR CHANNELS [J].

BLASCHKE, M ;

KELLER, BU ;

RIVOSECCHI, R ;

HOLLMANN, M ;

HEINEMANN, S ;

KONNERTH, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6528-6532

[7] Neuropharmacology of AMPA and kainate receptors [J].

Bleakman, D ;

Lodge, D .

NEUROPHARMACOLOGY, 1998, 37 (10-11) :1187-1204

[8]

Bleakman D, 1996, MOL PHARMACOL, V49, P581

[9] Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles [J].

Bleakman, D ;

Ballyk, BA ;

Schoepp, DD ;

Palmer, AJ ;

Bath, CP ;

Sharpe, EF ;

Woolley, ML ;

Bufton, HR ;

Kamboj, RK ;

Tarnawa, I ;

Lodge, D .

NEUROPHARMACOLOGY, 1996, 35 (12) :1689-1702

[10]

BLEAKMAN D, 1999, IN PRESS PHARM CHARA

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