Drug-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: A concise review

被引：73

作者：

Dlott, JS ^{[1
]}

Danielson, CF ^{[1
]}

Blue-Hnidy, DE ^{[1
]}

McCarthy, LJ ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Pathol & Lab Med Transfus Med, Indianapolis, IN 46202 USA

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2004年 / 8卷 / 02期

关键词：

hemolytic uremic syndrome; mitomycin; thrombotic microangiopathy; thrombotic thrombocytopenic purpura; ticlopidine;

D O I：

10.1111/j.1526-0968.2003.00127.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An extensive variety of drugs have been associated with thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS). Although a direct causal effect has usually not been proven, the cumulative evidence linking several drugs with TTP/HUS is strong. This paper reviews several categories of drugs including antineoplastics, immunotherapeutics and antiplatelet agents that have been reported to induce TTP/HUS. The pathogenesis of drug-induced TTP/HUS and the effectiveness of treatment regimens are also reviewed. A consensus on diagnostic criteria to accurately and consistently diagnose drug-induced TTP is needed.

引用

页码：102 / 111

页数：10

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