The application of gene therapy in autoimmune diseases

被引：24

作者：

Seroogy, CM ^{[1
]}

Fathman, CG ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

来源：

GENE THERAPY | 2000年 / 7卷 / 01期

关键词：

gene therapy autoimmune disease; CD4(+) T cell;

D O I：

10.1038/sj.gt.3301111

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The application of gene therapy in autoimmune disease represents a novel use of this technology. The goal of gene therapy in the treatment of autoimmune disease is to restore 'immune homeostasis' by countering the pro-inflammatory effects of the CD4(+) T cells in the lesions of autoimmunity. This can be accomplished by adoptive therapy with transduced T cells which can specifically home to the site of inflammation and secrete 'regulatory' protein(s) to ameliorate the inflammation or by direct targeting of the retroviral vector to activated T cells in the sites of inflammation. Transduction of autoantigen recognizing CD4(+) T cells, to secrete anti-inflammatory products, may become the 'magic bullet' to combat the ravages of autoimmune inflammation and tissue destruction.

引用

页码：9 / 13

页数：5

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