Enzymatic selective dehydration and skeleton rearrangement of paclitaxel precursors

被引：7

作者：

Lee, D ^{[1
]}

Kim, MJ ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

来源：

ORGANIC LETTERS | 1999年 / 1卷 / 06期

关键词：

D O I：

10.1021/ol990179m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives 2a-c are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids in good yields.

引用

页码：925 / 927

页数：3

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