Optical and Multimodality Molecular Imaging Insights Into Atherosclerosis

被引：134

作者：

Jaffer, Farouc A. ^{[1
,2
,3
,6
]}

Libby, Peter ^{[5
,6
]}

Weissleder, Ralph ^{[3
,4
,6
]}

机构：

[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[5] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Donald W Reynolds Cardiovasc Clin Res Ctr, Cambridge, MA 02138 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2009年 / 29卷 / 07期

关键词：

atherosclerosis; molecular imaging; optical; fluorescence; multimodality; nanoparticle; ULTRASMALL SUPERPARAMAGNETIC PARTICLES; TARGETED FUMAGILLIN NANOPARTICLES; EARLY-STAGE ATHEROSCLEROSIS; CATHEPSIN-K ACTIVITY; IN-VIVO; IRON-OXIDE; INTRAPLAQUE HEMORRHAGE; NONINVASIVE DETECTION; INFLAMMATION; PLAQUE;

D O I：

10.1161/ATVBAHA.108.165530

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Imaging approaches that visualize molecular targets rather than anatomic structures aim to illuminate vital molecular and cellular aspects of atherosclerosis biology in vivo. Several such molecular imaging strategies stand ready for rapid clinical application. This review describes the growing role of in vivo optical molecular imaging in atherosclerosis and highlights its ability to visualize atheroma inflammation, calcification, and angiogenesis. In addition, we discuss advances in multimodality probes, both in the context of multimodal imaging as well as multifunctional, or "theranostic," nanoparticles. This review highlights particular molecular imaging strategies that possess strong potential for clinical translation. (Arterioscler Thromb Vasc Biol. 2009; 29: 1017-1024.)

引用

页码：1017 / U98

页数：20

共 80 条

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