The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer

被引：222

作者：

Pálmer, HG

Larriba, MJ

García, JM

Orduñez-Moran, P

Peña, C

Peiró, S

Puig, I

Rodriguez, R

de la Fuente, R

Bernad, A

Pollán, M

Bonilla, F

Gamallo, C

de Herreros, AG

Muñoz, A

机构：

[1] Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, E-28029 Madrid, Spain

[2] Hosp Univ Puerta Hierro, E-28035 Madrid, Spain

[3] Univ Pompeu Fabra, Inst Municipal Invest Med, E-08003 Barcelona, Spain

[4] Hosp Virgen Salud, E-45004 Toledo, Spain

[5] Ctr Nacl Biotecnol, E-28049 Madrid, Spain

[6] Ctr Nacl Epidemiol, E-28029 Madrid, Spain

[7] Hosp Univ Princesa, E-28006 Madrid, Spain

来源：

NATURE MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1038/nm1095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several non-hypercalcemic analogs of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)(2)D-3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.

引用

页码：917 / 919

页数：3

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