Antitussive activity of iodo-resiniferatoxin in guinea pigs

被引：78

作者：

Trevisani, M ^{[1
]}

Milan, A

Gatti, R

Zanasi, A

Harrison, S

Fontana, G

Morice, AH

Geppetti, P

机构：

[1] Univ Ferrara, Ctr Excellence Study Inflammat, I-44100 Ferrara, Italy

[2] Univ Bologna, Dept Thorac Pumonary Dis, Unit Resp Physiopathol, Bologna, Italy

[3] Univ Florence, Dept Crit Care Med & Surg, Florence, Italy

[4] Univ Hull, Kingston Upon Hull HU6 7RX, N Humberside, England

来源：

THORAX | 2004年 / 59卷 / 09期

关键词：

D O I：

10.1136/thx.2003.012930

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Iodo-resiniferatoxin (I-RTX) has recently been described as an ultra potent antagonist of the transient receptor potential vanilloid-1 (TRPV1). Methods: The ability of I-RTX to inhibit cough induced by inhalation of two putative TRPV1 stimulants ( capsaicin and citric acid) was tested in non-anaesthetised guinea pigs. Results: Pretreatment with I-RTX either intraperitoneally (0.03 - 0.3 mumol/kg) or by aerosol (0.1 - 3 muM) reduced the number of coughs produced by inhalation of citric acid (0.25 M) and capsaicin ( 30 muM) in a dose dependent manner. Capsazepine (CPZ) also reduced citric acid and capsaicin induced cough, but the activity of I-RTX was 10 - 100 times more potent than CPZ in all the experimental conditions tested. Conclusions: I-RTX is a novel and potent antitussive drug which inhibits cough mediated by agents possibly acting via TRPV1 activation.

引用

页码：769 / 772

页数：4

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