A case of acquired idiopathic hemophilia successfully treated with immunosuppressive drugs and factor VIII concentrates

The appearance of circulating factor VIII:C (FVIII:C) inhibitors in nonhemophilic patients represents a rare condition characterized by spontaneous and often life-threatening bleeding. We describe a patient with acquired idiopathic hemophilia in whom immunosuppressive therapy associated with human FVIII infusion determined a prompt and complete disappearance of the inhibitor. Given the very low number of patients with acquired hemophilia and the lack of prospective randomized clinical trials published, we hope to contribute to a better definition of the therapeutic strategy in these patients.