Asymmetric Michael addition reactions using a chiral La-Na aminodiolate catalyst

被引：21

作者：

Prabagaran, N ^{[1
]}

Sundararajan, G ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(02)00240-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R,R)-(+)-2-[Benzyl-(2-hydroxy-2-phenylethyl)amino]-1-phenylethanol 1 is used as a chiral ligand in the synthesis of an optically active lanthanum-sodium amino diol complex LS-1. This heterobimetallic catalyst is quite effective its an asymmetric catalyst for various Michael addition reactions, H-1 NMR Study indicates the co-ordination of enone to the central lanthanum atom in LS-1. The reaction conditions were optimized and the adducts were obtained in high yield with moderate to high enantiomeric excess under extremely mild conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1053 / 1058

页数：6

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