Potent and selective thrombin inhibitors incorporating the constrained arginine mimic L-3-piperidyl(N-guanidino)alanine at P-1

被引：41

作者：

Levy, OE ^{[1
]}

Semple, JE ^{[1
]}

Lim, ML ^{[1
]}

Reiner, J ^{[1
]}

Rote, WE ^{[1
]}

Dempsey, E ^{[1
]}

Richard, BM ^{[1
]}

Zhang, E ^{[1
]}

Tulinsky, A ^{[1
]}

Ripka, WC ^{[1
]}

Nutt, RF ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT CHEM, E LANSING, MI 48824 USA

来源：

关键词：

D O I：

10.1021/jm960607j

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：4527 / 4530

页数：4

共 33 条

[1] BAJUSZ S, 1993, ADV EXP MED BIOL, V340, P91
[2] COLMAN RW, 1994, HEMOSTASIS THROMBOSI, P508
[3] COLMAN RW, 1994, HEMOSTASIS THROMBOSI, P3
[4] COUSINS GR, 1995, CIRCULATION, V92, P303
[5] EDIT JF, 1989, J CLIN INVEST, V84, P18
[6] PROTECTED LACTAM-BRIDGED DIPEPTIDES FOR USE AS CONFORMATIONAL CONSTRAINTS IN PEPTIDES
FREIDINGER, RM
PERLOW, DS
VEBER, DF
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (01) : 104 - 109
[7] Freindineger R. M., 1981, PEPTIDES SYNTHESIS S, P673
[8] HARKER LA, 1995, THROMB HAEMOSTASIS, V74, P464
[9] DESIGN AND SYNTHESIS OF POTENT AND HIGHLY SELECTIVE THROMBIN INHIBITORS
HILPERT, K
ACKERMANN, J
BANNER, DW
GAST, A
GUBERNATOR, K
HADVARY, P
LABLER, L
MULLER, K
SCHMID, G
TSCHOPP, TB
VANDEWATERBEEMD, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) : 3889 - 3901
[10] GUIDE TO ANTICOAGULANT-THERAPY .1. HEPARIN
HIRSH, J
FUSTER, V
[J]. CIRCULATION, 1994, 89 (03) : 1449 - 1468