7-O-Methylkaempferol and -quercetin Glycosides from the Whole Plant of Nervilia fordii

被引：34

作者：

Tian, Li-Wen ^{[1
,2
]}

Pei, Ying ^{[3
]}

Zhang, Ying-Jun ^{[1
]}

Wang, Yi-Fei ^{[3
]}

Yang, Chong-Ren ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 10039, Peoples R China

[3] Jinan Univ, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

CONSTITUENTS; FLAVONOIDS;

D O I：

10.1021/np800760p

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Five new 7-O-methylkaempferol and -quercetin glycosides, namely, nervili fordins A-E (1-5), were isolated from the whole plant of Nervilia fordii, together with seven known flavonoids (6, 7, and 9-13) and one known coumarin (8). Their structures were elucidated on the basis of extensive spectroscopic analyses, including HSQC, HMBC, ROESY, and chemical methods. Compounds 1-3 and 6-13 were evaluated for their anti-herpes simplex virus 1 (HSV-1) activity and cytotoxicity on African green monkey kidney cells (Vero cells) in vitro. Of the tested compounds, only esculetin (8) exhibited antiviral activity against HSV-1, while the aglycones (11-13) showed stronger cytotoxicity on Vero cells than their glycosides (1-3, 6, and 7).

引用

页码：1057 / 1060

页数：4

共 15 条

[1]

FURTHER FLAVONOL GLYCOSIDES FROM ANTHYLLIS-ONOBRYCHIOIDES [J].