Imprint cytology of core needle biopsy specimens of breast lesions -: A rapid approach to detecting malignancies, with comparison of cytologic and histopathologic analyses of 173 cases

被引:17
作者
Albert, US [1 ]
Duda, V [1 ]
Hadji, P [1 ]
Goerke, K [1 ]
Hild, F [1 ]
Bock, K [1 ]
Ramaswamy, A [1 ]
Schulz, KD [1 ]
机构
[1] Univ Marburg, Dept Gynecol Gynecol Endocrinol & Oncol, D-35037 Marburg, Germany
关键词
biopsy; needle; breast neoplasms; imprint cytology; core needle biopsy;
D O I
10.1159/000326226
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
OBJECTIVE: To investigate whether imprint cytology of core needle biopsy (CNB) specimens fr om breast lesions is a useful method of rapidly obtaining additional diagnostic information and potentially can be used to reduce the number of biopsies needed. STUDY DESIGN: Cytologic analysis was performed on 173 breast lesions and compared with their histopathologic diagnoses (143 malignant and 30 benign). For imprint cytology, one CNB specimen was rolled between two slides and stained with Diff-Quik and Papanicolaou stain. RESULTS: The diagnostic overall accuracy of Diff-Quik stain (Papanicolaou stain) was 95.4% (95.9%), with a sensitivity of 96.5% (97.2%), specificity of 90% (90%), positive predictive value of 97.8% (97.8%) and negative predictive value of 84.3% (87.0%). There was no statistically significant difference between the stains. Histopathologic analysis had an overall accuracy of 97.7%, with a sensitivity of 97.2%, specificity and positive predictive value of 100% and a negative predictive value of 88.2%. CONCLUSION: Imprint cytology of CNBs is a sensitive method of detecting malignancies in breast tumors. Diff-Quik is a rapid and reliable approach that can reduce the number of biopsies. Inadequate and suspicious cases should be evaluated based on complementary diagnostic procedures for breast lesions.
引用
收藏
页码:57 / 62
页数:6
相关论文
共 27 条
[1]  
ABRAMS J, 1989, PATHOL ANNU, V24, P167
[2]   Nondiagnostic stereotaxic core breast biopsy: Results of rebiopsy [J].
Dershaw, DD ;
Morris, EA ;
Liberman, L ;
Abramson, AF .
RADIOLOGY, 1996, 198 (02) :323-325
[3]   ANGIOSARCOMA AND OTHER VASCULAR TUMORS OF THE BREAST - PATHOLOGIC ANALYSIS AS A GUIDE TO PROGNOSIS [J].
DONNELL, RM ;
ROSEN, PP ;
LIEBERMAN, PH ;
KAUFMAN, RJ ;
KAY, S ;
BRAUN, DW ;
KINNE, DW .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1981, 5 (07) :629-642
[4]   A new method for the rapid microscopical diagnosis of tumours: With an account of 200 cases so examined. [J].
Dudgeon, LS ;
Patrick, CV .
BRITISH JOURNAL OF SURGERY, 1927, 15 (58) :250-261
[5]  
GIARD RWM, 1992, CANCER, V69, P2104, DOI 10.1002/1097-0142(19920415)69:8<2104::AID-CNCR2820690816>3.0.CO
[6]  
2-O
[7]   BREAST BIOPSY - A COMPARATIVE-STUDY OF STEREOTAXICALLY GUIDED CORE AND EXCISIONAL TECHNIQUES [J].
GISVOLD, JJ ;
GOELLNER, JR ;
GRANT, CS ;
DONOHUE, JH ;
SYKES, MW ;
KARSELL, PR ;
COFFEY, SL ;
JUNG, SH .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1994, 162 (04) :815-820
[8]   SOLID BREAST-LESIONS - DIAGNOSIS WITH US-GUIDED FINE-NEEDLE ASPIRATION BIOPSY [J].
GORDON, PB ;
GOLDENBERG, SL ;
CHAN, NHL .
RADIOLOGY, 1993, 189 (02) :573-580
[9]   US-GUIDED CORE BIOPSY OF THE BREAST WITH A COAXIAL SYSTEM [J].
KAPLAN, SS ;
RACENSTEIN, MJ ;
WONG, WS ;
HANSEN, GC ;
MCCOMBS, MM ;
BASSETT, LW .
RADIOLOGY, 1995, 194 (02) :573-575
[10]  
Klijanienko J, 1998, CANCER CYTOPATHOL, V84, P36, DOI 10.1002/(SICI)1097-0142(19980225)84:1<36::AID-CNCR6>3.0.CO