Syntheses and anti-Candida activity of cobalt(II) complexes of octanedioic acid (odaH2) and nonanedioic acid (ndaH2);: X-ray crystal structures of [Co(phen)3]oda•14H2O and [Co(phen)3]nda•11.5H2O (phen=1,10-phenanthroline)

被引：35

作者：

Geraghty, M ^{[1
]}

McCann, M

Devereux, M

McKee, V

机构：

[1] Natl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland

[2] Dublin Inst Technol, Dublin, Ireland

[3] Queens Univ, Sch Chem, Belfast, Antrim, North Ireland

来源：

INORGANICA CHIMICA ACTA | 1999年 / 293卷 / 02期

关键词：

crystal structures; cobalt complexes; dicarboxylic acid complexes; biological activity;

D O I：

10.1016/S0020-1693(99)00232-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cobalt(II) acetate tetrahydrate reacts with octanedioic acid and nonanedioic acid to give the cobalt(II) complexes [Co(oda)]. 3H(2)O (1) and [Co(nda)]. 4H(2)O (4), respectively. These two complexes react with an excess of 1,10-phenanthroline to form the tris-phenanthroline adducts [Co(phen)(3)]oda . 13H(2)O (2) and [Co(phen)(3)]nda . 10H(2)O (5). Crystals of the composition [Co(phen)(3)]oda . 14H(2)O (3) and [Co(phen)(3)]nda . 11.5H(2)O (6) were isolated from the respective mother liquors and the X-ray crystal structures show a [Co(phen)(3)](2+) dication within a lattice framework provided by the uncoordinated dicarboxylate dianion and water solvate molecules. The cobalt complexes inhibit the growth of the yeast Candida albicans. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：160 / 166

页数：7

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