An efficient solid-phase of 3-alkylamino-1,2,4-oxadiazoles

被引：11

作者：

Makara, GM ^{[1
]}

Schell, P ^{[1
]}

Hanson, K ^{[1
]}

Moccia, D ^{[1
]}

机构：

[1] NeoGenesis Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 29期

关键词：

benzotriazole; combinatorial; solid-phase; oxadiazole;

D O I：

10.1016/S0040-4039(02)01016-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solid-phase synthesis of substituted 3-alkylamino-1,2,4-oxadiazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-arboximidamides as key intermediates. Cyclization with hydroxylamine under mild conditions furnished the oxadiazole skeleton regioselectively in high yield and purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5043 / 5045

页数：3

共 18 条

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