Understanding IFNλ in rheumatoid arthritis

被引：11

作者：

de Groen, Rik A. ^{[1
]}

Liu, Bi-Sheng ^{[2
]}

Boonstra, Andre ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Erasmus MC, NL-3015 CE Rotterdam, Netherlands

[2] Leiden Univ, Dept Rheumatol, Med Ctr, NL-2300 RC Leiden, Netherlands

来源：

ARTHRITIS RESEARCH & THERAPY | 2014年 / 16卷 / 01期

关键词：

SYNOVIAL INFLAMMATION;

D O I：

10.1186/ar4445

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Unraveling the mechanisms underlying the inflammatory response in rheumatoid arthritis is crucial in order to better understand the disease and to develop novel therapeutic approaches. Although the effect of type I interferons on fibroblasts and in the context of rheumatoid arthritis has been described for some time, little is known on the effects of the type III interferons, also known as IFN lambda. In a previous issue, Xu and colleagues demonstrate that one of the members of the IFN. family, IFN lambda 1, enhances Toll-like receptor expression and consequently promotes the production of proinflammatory cytokines known to be involved in initiating and maintaining the inflammatory responses in rheumatoid arthritis.

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