Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1

被引:24
作者
Ahn, KS
Kim, JH
Oh, SR
Min, BS
Kinjo, J
Lee, HK
机构
[1] Korea Res Inst Biosci & Biotechnol, Immunomodulator Res Lab, Taejon 305600, South Korea
[2] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan
关键词
oleanane-type triterpenoid; fabaceous plant; intercellular adhesion molecule;
D O I
10.1248/bpb.25.1105
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-alpha-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the same activity as dexamethasone. On the other hand, the absence of hydroxyl group at C-24 position of sapogenin rather to increase ICAM-1 expression compared with the untreated control. We concluded that the activity of oleanane saponins and sapogenins against ICAM-1 expression are dependent upon the position of the hydroxyl group, and in particular upon the status of the C-21 and C-24 positions and of the glycosyl group at C-3 position.
引用
收藏
页码:1105 / 1107
页数:3
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