The rate of re-epithelialization across meshed skin grafts is increased with exposure to silver

被引:116
作者
Demling, RH [1 ]
DeSanti, MDL [1 ]
机构
[1] Brigham & Womens Hosp, Trauma & Burn Ctr, Dept Surg, Boston, MA 02115 USA
关键词
silver; epithelialization; moist healing;
D O I
10.1016/S0305-4179(01)00119-X
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The objective in this study was to determine whether exposure to pure silver increases the rate of re-epithelialization across a partial thickness wound. A meshed skin graft, placed on an excised burn wound was used as a healing model. Methods: The rate of meshed skin graft epithelial closure on an exposed bum using a moist healing environment was shown. A moistened silver delivery system (Acticoat) was compared with a standard xeroform and eight ply gauze dressing continually moistened with a 0.01% neomycin and polymyxin solution (NP). Twenty burn patients with deep burns of over 15% of TBS were excised and grafted with 2:1 meshed grafts. One graft area was treated with the antibiotic solution and another with the silver delivery. The meshed graft was performed within 3 days of injury. Results: No infections were noted and quantitative swab cultures gave less than 10(2) bacteria in a] I cases at wound closure. At day 7, re-epithelialization was complete with silver and 55% closed with NP solution. Wound closure was complete in the NP solution group at day 10. Silver increased re-epithelialization rate by over 40%, a significant increase. Graft take was over 95% in both groups. Conclusion: Silver released in a moist wound surface environment significantly increases the rate of re-epithelialization compared to a standard antibiotic solution. (C) 2002 Elsevier Science Ltd. and ISBI. All rights reserved.
引用
收藏
页码:264 / 266
页数:3
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