New Insights into the Interactions between Dendrimers and Surfactants: 2. Design of New Drug Formulations Based on Dendrimer-Surfactant Aggregates

被引：52

作者：

Cheng, Yiyun ^{[1
,2
,3
]}

Wu, Qinglin ^{[2
,3
]}

Li, Yiwen ^{[1
]}

Hu, Jingjing ^{[1
]}

Xu, Tongwen ^{[1
]}

机构：

[1] Univ Sci & Technol China, Lab Funct Membranes, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[3] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 24期

关键词：

NOE NMR-SPECTROSCOPY; POLY(AMIDOAMINE) DENDRIMERS; TRANSDERMAL DELIVERY; CONTROLLED-RELEASE; IONIC SURFACTANTS; FLUORESCENCE; ASSEMBLIES; CHEMISTRY;

D O I：

10.1021/jp9021618

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interactions between dendrimers and surfactants led to the formation of aggregates dispersed in aqueous solutions. The potential of the resulting dendrimer-surfactant aggregates as new drug formulations was evaluated. The size, morphology, and stability of the aggregates and the localization of drugs in them were determined by dynamic laser light scattering, atomic force microscopy, agarose gel electrophoresis, and nuclear magnetic resonance studies. The drug-loaded aggregates have a spherical shape and an average size of 40 nm. The drug-loading efficiency of dendrimers is significantly influenced in the presence of surfactants. The release rate of the drugs from the dendrimer-surfactant aggregates can be modulated by varying the amount of surfactant in the aggregates. The dendrimer-surfactant aggregates are promising carriers for hydrophobic drugs in transdermal administration routes.

引用

页码：8339 / 8346

页数：8

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