Polymorphisms of genes controlling homocysteine/folate metabolism and cognitive function

被引：41

作者：

Barbaux, S

Plomin, R

Whitehead, AS

机构：

[1] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Ctr Pharmacogenet, Philadelphia, PA 19104 USA

[3] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England

来源：

NEUROREPORT | 2000年 / 11卷 / 05期

关键词：

cognitive function; cystathionine beta-synthase; folate; homocysteine; polymorphism;

D O I：

10.1097/00001756-200004070-00044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Elevated concentrations of the amino acid homocysteine and/or folate deficiency have been reported to affect neural development/function in both human patients and animal models. We have investigated the distribution of functional polymorphisms in genes involved in homocysteine/folate metabolism in children with high IQ and in children with average IQ. No differences in the frequencies of genetic variants in the methionine synthase or methylenetetrahydrofolate reductase genes were found. However, the cystathionine beta-synthase (CBS) 844ins68 allele was significantly underrepresented in children with high IQ. The mechanism by which a functional genetic variant in the CBS gene may influence cognitive function remains to be determined. NeuroReport 11:1133-1136 (C) 2000 Lippincott Williams & Wilkins.

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页码：1133 / 1136

页数：4

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