Anti-Helicobacter pylori activity of plants used in Mexican traditional medicine for gastrointestinal disorders

Aim of the study: Helicobacter pylori is the major etiological agent of chronic active gastritis and peptic ulcer disease and is linked to gastric carcinoma. Treatment to eradicate the bacteria failed in many cases. mainly due to antibiotic resistance, hence the necessity of developing better therapeutic regimens. Mexico has an enormous unexplored potential of medicinal plants. This work evaluates the in vitro anti-H. pylori activity of 53 plants used in Mexican traditional medicine for gastrointestinal disorders. Materials and methods: To test the in vitro antibacterial activity, agar dilution and broth dilution methods were used for aqueous and methanolic extracts, respectively. Results: Aqueous extracts of Artemisia ludoviciana subsp. mexicana, Cuphea aequipetala. Ludwigia repens,and Mentha x piperita (MIC 125 to < 250 mu g/ml)as well as methanolic extracts of Persea americana, Annona cherimola, Guaiacum coulteri, and Moussonia deppeana (MIC < 7.5 to 15.6 mu g/ml) showed the highest inhibitory effect. Conclusions: The results contribute to understanding the mode of action of the studied medicinal plants and for detecting plants with high anti-Helicobacter pylori activity. (C) 2009 Elsevier Ireland Ltd. All rights reserved.