CD4+ CD25highforkhead box protein 3+ regulatory T lymphocytes suppress interferon-γ and CD107 expression in CD4+and CD8+ T cells from tuberculous pleural effusions
被引:25
作者:
Geffner, L.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Geffner, L.
[1
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Basile, J. I.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Basile, J. I.
[1
]
Yokobori, N.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Yokobori, N.
[1
]
Sabio y Garcia, C.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Sabio y Garcia, C.
[1
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Musella, R.
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机构:
Hosp Francisco Muniz, Dept Neumonol, Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Musella, R.
[2
]
Castagnino, J.
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机构:
Hosp Francisco Muniz, Dept Neumonol, Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Castagnino, J.
[2
]
Sasiain, M. C.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
Sasiain, M. C.
[1
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de la Barrera, S.
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Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, ArgentinaAcad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
de la Barrera, S.
[1
]
机构:
[1] Acad Nacl Med Buenos Aires, IMEX CONICET, RA-1425 Buenos Aires, DF, Argentina
[2] Hosp Francisco Muniz, Dept Neumonol, Buenos Aires, DF, Argentina
Tuberculous pleural effusion is characterized by a T helper type 1 (Th1) profile, but an excessive Th1 response may also cause tissue damage that might be controlled by regulatory mechanisms. In the current study we investigated the role of regulatory T cells (T-reg) in the modulation of Th1 responses in patients with tuberculous (TB) pleurisy. Using flow cytometry we evaluated the proportion of T-reg (CD4(+)CD25(high)forkhead box protein 3(+)), interferon (IFN)- and interleukin (IL)-10 expression and CD107 degranulation in peripheral blood (PB) and pleural fluid (PF) from patients with TB pleurisy. We demonstrated that the proportion of CD4(+)CD25(+), CD4(+)CD25(high)FoxP3(+) and CD8(+)CD25(+) cells were increased in PF compared to PB samples. Mycobacterium tuberculosis stimulation increased the proportion of CD4(+)CD25(low/neg)IL-10(+) in PB and CD4(+)CD25(low/neg)IFN-(+) in PF; meanwhile, CD25(high) mainly expressed IL-10 in both compartments. A high proportion of CD4(+)CD107(+) and CD8(+)CD107(+) cells was observed in PF. T-reg depletion enhanced the in-vitro M. tuberculosis-induced IFN- and CD4(+) and CD8(+) degranulation responses and decreased CD4(+)IL-10(+) cells in PF. Our results demonstrated that in TB pleurisy T-reg cells effectively inhibit not only IFN- expression but also the ability of CD4(+) and CD8(+) cells to degranulate in response to M. tuberculosis.
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Dlugovitzky, D
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Bay, ML
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Bay, ML
;
Rateni, L
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Rateni, L
;
Urizar, L
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Urizar, L
;
Rondelli, CFM
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Rondelli, CFM
;
Largacha, C
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Largacha, C
;
Farroni, MA
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h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Farroni, MA
;
Molteni, O
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机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Molteni, O
;
Bottasso, OA
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机构:
Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, ArgentinaFac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
机构:
Natl Inst Hyg, Dept Immunol Virol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Fenniri, L.
;
Toossi, Z.
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h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Toossi, Z.
;
Aung, H.
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机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Aung, H.
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El Iraki, G.
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机构:
Hop Moulay Youssef, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Iraki, G.
;
Bourkkadi, J.
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机构:Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Bourkkadi, J.
;
Benamor, J.
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h-index: 0
机构:
Hop Moulay Youssef, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Benamor, J.
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Laskri, A.
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h-index: 0
机构:Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Laskri, A.
;
Berrada, N.
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci Rabat, Dept Biol, Lab Biochim Immunol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Berrada, N.
;
Benjouad, A.
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h-index: 0
机构:
Fac Sci Rabat, Dept Biol, Lab Biochim Immunol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Benjouad, A.
;
Mayanja-Kizza, H.
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机构:
Makerere Univ, Dept Med, Kampala, UgandaCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Mayanja-Kizza, H.
;
Betts, M. R.
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h-index: 0
机构:
Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Betts, M. R.
;
El Aouad, R.
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h-index: 0
机构:
Natl Inst Hyg, Dept Immunol Virol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Aouad, R.
;
Canaday, D. H.
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机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Dlugovitzky, D
;
Bay, ML
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Bay, ML
;
Rateni, L
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Rateni, L
;
Urizar, L
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Urizar, L
;
Rondelli, CFM
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Rondelli, CFM
;
Largacha, C
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Largacha, C
;
Farroni, MA
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Farroni, MA
;
Molteni, O
论文数: 0引用数: 0
h-index: 0
机构:Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
Molteni, O
;
Bottasso, OA
论文数: 0引用数: 0
h-index: 0
机构:
Fac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, ArgentinaFac Ciencias Med Rosario, Inst Inmunol, RA-2000 Rosario, Santa Fe, Argentina
机构:
Natl Inst Hyg, Dept Immunol Virol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Fenniri, L.
;
Toossi, Z.
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Toossi, Z.
;
Aung, H.
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h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Aung, H.
;
El Iraki, G.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Moulay Youssef, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Iraki, G.
;
Bourkkadi, J.
论文数: 0引用数: 0
h-index: 0
机构:Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Bourkkadi, J.
;
Benamor, J.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Moulay Youssef, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Benamor, J.
;
Laskri, A.
论文数: 0引用数: 0
h-index: 0
机构:Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Laskri, A.
;
Berrada, N.
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci Rabat, Dept Biol, Lab Biochim Immunol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Berrada, N.
;
Benjouad, A.
论文数: 0引用数: 0
h-index: 0
机构:
Fac Sci Rabat, Dept Biol, Lab Biochim Immunol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Benjouad, A.
;
Mayanja-Kizza, H.
论文数: 0引用数: 0
h-index: 0
机构:
Makerere Univ, Dept Med, Kampala, UgandaCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Mayanja-Kizza, H.
;
Betts, M. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
Betts, M. R.
;
El Aouad, R.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Hyg, Dept Immunol Virol, Rabat, MoroccoCase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA
El Aouad, R.
;
Canaday, D. H.
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USACase Western Reserve Univ, Sch Med, Div Infect Dis, Cleveland, OH 44106 USA