Combinatorial chemistry and high-throughput screening for the discovery of organocatalysts

被引：34

作者：

Fonseca, MH ^{[1
]}

List, B ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2004年 / 8卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2004.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In recent years, interest in organocatalysis, the catalysis with small organic molecules, has been revitalized. Independently, high-throughput-screening and combinatorial chemistry became practical methodologies in the discovery of novel catalytic entities. The logical extension of these methodologies to organocatalysis has led to several interesting results, which are highlighted in this review.

引用

页码：319 / 326

页数：8

共 44 条

[1] The discovery of catalytically active peptides through combinatorial chemistry [J].

Berkessel, A .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (03) :409-419

[2] First example of N-heterocyclic carbenes as catalysts for living polymerization:: Organocatalytic ring-opening polymerization of cyclic esters [J].

Connor, EF ;

Nyce, GW ;

Myers, M ;

Möck, A ;

Hedrick, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (06) :914-915

[3] Selection of enantioselective acyl transfer catalysts from a pooled peptide library through a fluorescence-based activity assay: An approach to kinetic resolution of secondary alcohols of broad structural scope [J].

Copeland, GT ;

Miller, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (27) :6496-6502

[4] A chemosensor-based approach to catalyst discovery in solution and on solid support [J].

Copeland, GT ;

Miller, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (17) :4306-4307

[5] N-heterocyclic carbenes as versatile nucleophilic catalysts for transesterification/acylation reactions [J].

Grasa, GA ;

Kissling, RM ;

Nolan, SP .

ORGANIC LETTERS, 2002, 4 (21) :3583-3586

[6] A peptide-based catalyst approach to regioselective functionalization of carbohydrates [J].

Griswold, KS ;

Miller, SJ .

TETRAHEDRON, 2003, 59 (45) :8869-8875

[7] 4-DIALKYLAMINOPYRIDINES AS ACYLATION CATALYSTS .4. 4-DIALKYLAMINOPYRIDINES AS HIGHLY ACTIVE ACYLATION CATALYSTS [J].

HOFLE, G ;

STEGLICH, W ;

VORBRUGGEN, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1978, 17 (08) :569-&

[8] Dual catalyst control in the amino acid-peptide-catalyzed enantioselective Baylis-Hillman reaction [J].

Imbriglio, JE ;

Vasbinder, MM ;

Miller, SJ .

ORGANIC LETTERS, 2003, 5 (20) :3741-3743

[9]

Janes LE, 1998, CHEM-EUR J, V4, P2324, DOI 10.1002/(SICI)1521-3765(19981102)4:11<2324::AID-CHEM2324>3.3.CO

[10]

2-9

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