Uterine artery embolization in sheep: Comparison of acute effects with polyvinyl alcohol particles and calibrated microspheres

被引:118
作者
Pelage, JP
Laurent, A
Wassef, M
Bonneau, M
Germain, D
Rymer, R
Flaud, P
Martal, J
Merland, JJ
机构
[1] Univ Paris, CNRS, LNAT, Ctr Rech Assoc Claude Bernard, Paris, France
[2] Ctr Res Intervent Radiol, Jouy En Josas, France
[3] Hop Lariboisiere, Dept Body & Vasc Imaging, F-75475 Paris, France
[4] Hop Lariboisiere, Dept Neuroradiol, F-75475 Paris 10, France
[5] INRA, Dept Anim Physiol, Jouy En Josas, France
关键词
animals; arteries; chemotherapeutic embolization; uterine; experimental study sheep; interventional procedures; uterineneoplasms; therapeutic radiology;
D O I
10.1148/radiol.2242010847
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To compare the effects on the myometrium of polyvinyl alcohol (PVA) particles and calibrated microspheres (MS) in embolization of the uterine arteries in sheep. MATERIALS AND METHODS: Superselective and bilateral embolization of the uterine arteries was performed with PVA particles and calibrated MS within 24 hours after artificial ovulation in 26 adult nonpregnant sheep, PVA particles of four diameters, 150-250, 250-400, 400-600, and 600-1,000 mum, were compared with calibrated MS of similar diameters, 100-300, 300-500, 500-700, and 700900 mum, in eight groups of sheep. Evaluation was based on histopathologic study of uterus, ovaries, and vascular pedicles after sacrifice 5 days after embolization. The scores of necrosis, the diameter of occluded arteries, and the number of particles were determined. The scores of uterine necrosis were compared by using nonparametric tests (Mann-Whitney U and Kruskal-Wallis). Spearman rank test was used for correlations. RESULTS: PVA particles clumped more readily than did MS. Small particles had a higher score (P = .02) of uterine necrosis than did large particles. PVA particles produced more necrosis than did MS. Size of MS and diameter of occluded arteries showed significant correlation (p = 0.762, P < .001). Size of PVA particles and diameter of occluded arteries showed no correlation. PVA particles occluded vessels of a wider range of size than did calibrated MS. CONCLUSION: PVA particles are associated with intense uterine necrosis and extensive arterial occlusion regardless of size. Calibrated MS, which are associated with less uterine necrosis, permit a segmental arterial occlusion correlated with size. (C) RSNA, 2002.
引用
收藏
页码:436 / 445
页数:10
相关论文
共 39 条
[1]  
AZIZ A, 1998, ACTA OBSTET GYNECOL, V105, P235
[2]  
BARONE R, 1976, ANATOMIE COMP MAMMIF, V4
[3]   Polyvinyl alcohol foam particle sizes and concentrations injectable through microcatheters [J].
Barr, JD ;
Lemley, TJ ;
Petrochko, CN .
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 1998, 9 (01) :113-118
[4]  
Beaujeux R, 1996, AM J NEURORADIOL, V17, P541
[5]  
Bendszus M, 2000, AM J NEURORADIOL, V21, P255
[6]  
CARLSON KJ, 1993, NEW ENGL J MED, V328, P856
[7]  
DERDEYN CP, 1995, AM J NEURORADIOL, V16, P307
[8]  
Derdeyn CP, 1997, AM J NEURORADIOL, V18, P647
[9]   DEXTRAN MICROSPHERE EMBOLIZATION - EXPERIMENTAL AND CLINICAL-EXPERIENCE WITH RADIOLOGIC-PATHOLOGICAL CORRELATION [J].
DION, JE ;
RANKIN, RN ;
VINUELA, F ;
FOX, AJ ;
WALLACE, AC ;
MERVART, M .
RADIOLOGY, 1986, 160 (03) :717-721
[10]  
FARRER-BROWN G, 1970, Journal of Obstetrics and Gynaecology of the British Commonwealth, V77, P673