Reprogramming metastatic tumour cells with embryonic microenvironments

被引：370

作者：

Hendrix, Mary J. C. ^{[1
]}

Seftor, Elisabeth A.

Seftor, Richard E. B.

Kasemeier-Kulesa, Jennifer

Kulesa, Paul M.

Postovit, Lynne-Marie

机构：

[1] Univ Feinburg, Sch Med, Robert H Lurie Comprehens Canc Ctr, Childrens Mem Res Ctr,Canc Biol & Epigenom Progra, Chicago, IL 60614 USA

[2] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 04期

关键词：

D O I：

10.1038/nrc2108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.

引用

页码：246 / 255

页数：10

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