The evolving pathogenesis of systemic vasculitis

被引:17
作者
Savage, COS [1 ]
机构
[1] Univ Birmingham, Div Med Sci, Birmingham B15 2TT, W Midlands, England
关键词
antineutrophil cytoplasmic antibodies (ANCA); autoantibodies; endothelium; microscopic polyangiitis; neutrophils; vasculitis; Wegener's granulomatosis;
D O I
10.7861/clinmedicine.2-5-458
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The primary small vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflammation and associated with development of antineutrophil cytoplasmic antibodies. Multiple organs are attacked including the lungs and kidneys. Increasing knowledge of pathogenesis suggests that the antibodies activate neutrophils inappropriately, leading to endothelial and vascular damage. Cytokines such as tumour necrosis factor (TNF) can facilitate the damage by priming neutrophils and activating endothelial cells. Understanding pathogenesis can help to rationalise existing therapies and indicate new approaches to therapy such as the use of agents that inhibit the effects of TNF.
引用
收藏
页码:458 / 464
页数:7
相关论文
共 39 条
[1]   Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades:: comparison with conventional Fcγ receptor ligation [J].
Ben-Smith, A ;
Dove, SK ;
Martin, A ;
Wakelam, MJO ;
Savage, COS .
BLOOD, 2001, 98 (05) :1448-1455
[2]   IL-1 beta production by human polymorphonuclear leucocytes stimulated by antineutrophil cytoplasmic autoantibodies: Relevance to systemic vasculitis [J].
Brooks, CJ ;
King, WJ ;
Radford, DJ ;
Adu, D ;
McGrath, M ;
Savage, COS .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 106 (02) :273-279
[3]  
Carvalho D, 1999, ARTHRITIS RHEUM-US, V42, P631, DOI 10.1002/1529-0131(199904)42:4<631::AID-ANR5>3.0.CO
[4]  
2-X
[5]   T lymphocyte adhesion mechanisms within inflamed human kidney -: Studies with a Stamper-Woodruff assay [J].
Chakravorty, SJ ;
Howie, AJ ;
Cockwell, P ;
Adu, D ;
Savage, COS .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (02) :503-514
[6]   Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis [J].
Cockwell, P ;
Brooks, CJ ;
Adu, D ;
Savage, COS .
KIDNEY INTERNATIONAL, 1999, 55 (03) :852-863
[7]   In situ analysis of C-C chemokine mRNA in human glomerulonephritis [J].
Cockwell, P ;
Howie, AJ ;
Adu, D ;
Savage, COS .
KIDNEY INTERNATIONAL, 1998, 54 (03) :827-836
[8]  
Cunningham MA, 1999, J AM SOC NEPHROL, V10, P499
[9]   SEGMENTAL NECROTIZING GLOMERULONEPHRITIS WITH ANTI-NEUTROPHIL ANTIBODY - POSSIBLE ARBOVIRUS ETIOLOGY [J].
DAVIES, DJ ;
MORAN, JE ;
NIALL, JF ;
RYAN, GB .
BMJ-BRITISH MEDICAL JOURNAL, 1982, 285 (6342) :606-606
[10]   The value of pulse cyclophosphamide in ANCA-associated vasculitis: meta-analysis and critical review [J].
de Groot, K ;
Adu, D ;
Savage, COS .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (10) :2018-2027