Hematopoietic Stem and Progenitor Cells and the Inflammatory Response

被引：19

作者：

Jaiswal, Siddhartha ^{[1
]}

Weissman, Irving L. ^{[1
]}

机构：

[1] Stanford Univ, Beckman Ctr B257, Sch Med, Stanford, CA 94305 USA

来源：

CANCER VACCINES | 2009年 / 1174卷

关键词：

hematopoietic stem cells; inflammation; phagocytosis; COLONY-STIMULATING FACTOR; HOMING RECEPTOR; IDENTIFICATION; BINDING; CD47; MOBILIZATION; MIGRATION; INVIVO; BLOOD;

D O I：

10.1111/j.1749-6632.2009.04930.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells of the vertebrate immune system are continuously regenerated by division of hematopoietic stem cells (HSCs) into differentiated effector cells. Classically, HSCs were thought to reside primarily in the bone marrow niche where they produced mature progeny that migrated from the marrow to repopulate the peripheral immune system. However, emerging evidence has established that hematopoietic stem and progenitor cells (HSPCs) are themselves mobile and able to repopulate ectopic niches and contribute more directly to inflammatory responses in the periphery. How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown.

引用

页码：118 / 121

页数：4

共 23 条

[1] CYCLOPHOSPHAMIDE TREATMENT EXPANDS THE CIRCULATING HEMATOPOIETIC STEM-CELL POOL IN DOGS [J].

ABRAMS, RA ;

MCCORMACK, K ;

BOWLES, C ;

DEISSEROTH, AB .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (05) :1392-1399

[2] ALPHA-4-BETA-7-INTEGRIN MEDIATES LYMPHOCYTE BINDING TO THE MUCOSAL VASCULAR ADDRESSIN MADCAM-1 [J].

BERLIN, C ;

BERG, EL ;

BRISKIN, MJ ;

ANDREW, DP ;

KILSHAW, PJ ;

HOLZMANN, B ;

WEISSMAN, IL ;

HAMANN, A ;

BUTCHER, EC .

CELL, 1993, 74 (01) :185-195

[3] CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells [J].

Blazar, BR ;

Lindberg, FP ;

Ingulli, E ;

Panoskaltsis-Mortari, A ;

Oldenborg, PA ;

Iizuka, K ;

Yokoyama, WM ;

Taylor, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :541-549

[4] Integrin-associated protein (CD47) and its ligands [J].

Brown, EJ ;

Frazier, WA .

TRENDS IN CELL BIOLOGY, 2001, 11 (03) :130-135

[5]

DAILEY MO, 1985, J MOL CELL IMMUNOL, V2, P27

[6] LPS-binding proteins and receptors [J].

Fenton, MJ ;

Golenbock, DT .

JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 64 (01) :25-32

[7] STEEL FACTOR INFLUENCES THE DISTRIBUTION AND ACTIVITY OF MURINE HEMATOPOIETIC STEM-CELLS INVIVO [J].

FLEMING, WH ;

ALPERN, EJ ;

UCHIDA, N ;

IKUTA, K ;

WEISSMAN, IL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3760-3764

[8] LYMPHOCYTE HOMING RECEPTORS [J].

GALLATIN, M ;

STJOHN, TP ;

SIEGELMAN, M ;

REICHERT, R ;

BUTCHER, EC ;

WEISSMAN, IL .

CELL, 1986, 44 (05) :673-680

[9]

GOODMAN JOAN WRIGHT, 1962, BLOOD JOUR HEMATOL, V19, P702

[10] IDENTIFICATION OF A MURINE PEYERS PATCH SPECIFIC LYMPHOCYTE HOMING RECEPTOR AS AN INTEGRIN MOLECULE WITH AN ALPHA-CHAIN HOMOLOGOUS TO HUMAN VLA-4-ALPHA [J].

HOLZMANN, B ;

MCINTYRE, BW ;

WEISSMAN, IL .

CELL, 1989, 56 (01) :37-46

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