The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials

被引：40

作者：

Boers, Maarten

Tangelder, Marco J. D.

van Ingen, Hein

Fort, John G.

Goldstein, Jay L.

机构：

[1] VU Univ Med Ctr, Dept Clin Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands

[2] Univ Hosp Utrecht, Utrecht, Netherlands

[3] Adolor Corp, Exton, PA USA

[4] Univ Illinois, Dept Med, Chicago, IL USA

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 03期

关键词：

D O I：

10.1136/ard.2006.055012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The risk of major ulcer complications on treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is known to increase exponentially with age. However, in a pooled analysis of 12 trial arms, the incidence of endoscopic ulcers on treatment with NSAID was found to increase with age in a roughly linear fashion. Thus, it is concluded that increasing age is associated with both more frequent and more serious NSAID gastropathy.

引用

页码：417 / 418

页数：2

共 5 条

[1]

FRIES JF, 1991, J RHEUMATOL S, V28, P6

[2] Incidence of serious upper gastrointestinal bleeding/perforation in the general population:: Review of epidemiologic studies [J].