CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro

被引：72

作者：

Krohn, Alexander ^{[1
]}

Song, Yao-Hua ^{[1
]}

Muehlberg, Fabian ^{[1
]}

Droll, Lilly ^{[1
]}

Beckmann, Christoph ^{[1
]}

Alt, Eckhard ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2009年 / 280卷 / 01期

关键词：

Cancer stem cells; CXCR4; Spheroid; CANCER STEM-CELLS; BREAST-CANCER; PANCREATIC-CANCER; CHEMOKINE RECEPTOR-4; PROSTATE-CANCER; BONE-MARROW; EXPRESSION; METASTASIS; LIGAND; INVOLVEMENT;

D O I：

10.1016/j.canlet.2009.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Stem cells have been found to be involved in breast cancer growth, but the specific contribution of cancer stem cells in tumor biology, including metastasis, is still uncertain. We found that murine breast cancer cell lines 4T1, 4TO7, 167Farn and 67NR contains cancer stem cells defined by CXCR4 expression and their capability of forming spheroids in suspension culture. Importantly, we showed that CXCR4 expression is essential for tumor invasiveness because both CXCR4 neutralizing antibody and shRNA knockdown of the CXCR4 receptor significantly reduced tumor cell invasion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：65 / 71

页数：7

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