Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis

被引：9

作者：

Luna, T

Mazzolla, R

Romano, G

Blasi, E

机构：

[1] UNIV PERUGIA,DEPT EXPT MED & BIOCHEM SCI,MICROBIOL SECT,I-06122 PERUGIA,ITALY

[2] LEPETIT RES CTR,GERENZANO,VARESE,ITALY

[3] UNIV MODENA,DEPT BIOMED SCI,I-41100 MODENA,ITALY

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 03期

关键词：

D O I：

10.1128/AAC.41.3.706

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA),was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.

引用

收藏

页码：706 / 708

页数：3

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