Enzymatic asymmetrisation of prochiral alpha,alpha-disubstituted-malonates and -1,3-propanediols: Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine

被引：39

作者：

Fadel, A

Arzel, P

机构：

[1] Lab. des Carbocycles (Associe Au C., I.C.M.O. Bât. 420, Université de Paris-Sud

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(96)00538-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Formal asymmetric syntheses of (-)-aphanorphine and (+)-eptazocine are reported via the two key intermediates 3a and 3b obtained in 94-97% ee, from the readily available chirons (R)-5 and (R)-9. Which resulting from enzyme-catalysed asymmetrisation of prochiral alpha,alpha-disubstituted-1,3-propanediols and -malonates respectively. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：371 / 374

页数：4

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