Mechanism of action of hemolysin III from Bacillus cereus

被引：89

作者：

Baida, GE

Kuzmin, NP

机构：

[1] Inst. of Biochem. and Physiol. of M., Russian Academy of Sciences, Pushchino, Moscow Region

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1996年 / 1284卷 / 02期

关键词：

hemolysin III; pore formation; (Bacillus cereus);

D O I：

10.1016/S0005-2736(96)00168-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacillus cereus hemolysin III activity was tested in crude extracts from Escherichia coli carrying the hly-III gene. It was concluded that hemolysin III is a pore-forming hemolysin with a functional pore diameter of about 3-3.5 nm. Hemolysis occurs in at least three steps: (i) the temperature-dependent binding of the HIV-III monomers to the erythrocyte membrane: (ii) the temperature-dependent formation of the transmembrane oligomeric pore; (iii) the temperature-independent erythrocyte lysis.

引用

页码：122 / 124

页数：3

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