Self-assembled signaling aptamer DNA arrays for protein detection

被引：129

作者：

Lin, Chenxiang

Katilius, Evaldas

Liu, Yan

Zhang, Junping

Yan, Hao ^{[1
]}

机构：

[1] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

[2] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 32期

关键词：

DNA arrays; molecular recognition; protein detection; self-assembly; signaling aptamers;

D O I：

10.1002/anie.200600438

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：5296 / 5301

页数：6

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