Synthesis and characterization of thermoset biodegradable elastomers based on star-poly(ε-caprolactone-co-D,L-lactide)

被引：78

作者：

Amsden, B ^{[1
]}

Wang, S

Wyss, U

机构：

[1] Queens Univ, Dept Chem Engn, Kingston, ON K7L 3N6, Canada

[2] Queens Univ, Dept Mech Engn, Kingston, ON K7L 3N6, Canada

来源：

BIOMACROMOLECULES | 2004年 / 5卷 / 04期

关键词：

D O I：

10.1021/bm034538j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biodegradable elastomers represent a useful class of biomaterials. In this paper, we synthesize thermoset elastomers by utilizing the living nature of ring-opening polymerization of a star copolymer of D,L-lactide and epsilon-caprolactone initiated with glycerol and catalyzed by stannous 2-ethylhexanoate. The star copolymers were synthesized of varying molecular weight and monomer composition and cross-linked by compression molding using a dilactone, bis(epsilon-caprolactone-4-yl)propane dissolved in epsilon-caprolactone monomer. The elastomers were then characterized by differential scanning calorimetry and uniaxial tensile testing and their physical properties related to the nature of the star copolymer prepolymers. The results demonstrate a means of predictably altering the elastomer physical properties by adjusting the star copolymer prepolymer initial molecular weight and monomer ratio.

引用

页码：1399 / 1404

页数：6

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