Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation

被引：671

作者：

Mahdavi, J

Sondén, B

Hurtig, M

Olfat, FO

Forsberg, L

Roche, N

Ångström, J

Larsson, T

Teneberg, S

Karlsson, KA

Altraia, S

Wadström, T

Kersulyte, D

Berg, DE

Dubois, A

Petersson, C

Magnusson, KE

Norberg, T

Lindh, F

Lundskog, BB

Arnqvist, A

Hammarström, L

Borén, T

机构：

[1] Umea Univ, Dept Odontol Oral Microbiol, SE-90187 Umea, Sweden

[2] Swedish Inst Infect Dis Control, SE-17182 Solna, Sweden

[3] Univ Gothenburg, Inst Med Biochem, SE-40530 Gothenburg, Sweden

[4] Univ Tartu, Inst Mol & Cell Biol, EE-51010 Tartu, Estonia

[5] Lund Univ, Dept Infect Dis & Med Microbiol, SE-22362 Lund, Sweden

[6] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[7] Uniformed Serv Univ Hlth Sci, Dept Med, Gastrointestinal & Liver Studies Lab, Bethesda, MD 20814 USA

[8] Linkoping Univ, Dept Mol & Clin Med, Div Med Microbiol, SE-58185 Linkoping, Sweden

[9] Swedish Univ Agr Sci, Dept Chem, SE-75007 Uppsala, Sweden

[10] IsoSep AB, SE-14636 Tullinge, Sweden

[11] Umea Univ, Dept Med Biosci Clin Cytol, SE-90187 Umea, Sweden

[12] Umea Univ, Dept Biol Mol, SE-90187 Umea, Sweden

[13] Karolinska Inst, Novum, Ctr Biotechnol, SE-14157 Huddinge, Sweden

来源：

SCIENCE | 2002年 / 297卷 / 5581期

关键词：

D O I：

10.1126/science.1069076

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid binding adhesin (SabA) was isolated with the retagging method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

引用

页码：573 / 578

页数：6

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