Strategies for developing vaccines against H5N1 influenza A viruses

被引：69

作者：

Horimoto, Taisuke ^{[1
]}

Kawaoka, Yoshihiro ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Div Virol,Dept Microbiol & Immunol,Minato Ku, Tokyo 1088639, Japan

来源：

TRENDS IN MOLECULAR MEDICINE | 2006年 / 12卷 / 11期

关键词：

D O I：

10.1016/j.molmed.2006.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 subtype) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse-genetics-based inactivated vaccines have been prepared according to World Health Organization (WHO) recommendations and are now undergoing clinical evaluation in several countries. Here, we review the current strategies for the development of H5N1 influenza vaccines, and future directions for vaccine development.

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页码：506 / 514

页数：9

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