Retinal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus - Comparison of measurements obtained by retinal thickness analysis and optical coherence tomography

被引:41
作者
Pires, I
Bernardes, RC
Lobo, CL
Soares, MA
Cunha-Vaz, JG
机构
[1] Univ Hosp Coimbra, Dept Ophthalmol, P-3000 Coimbra, Portugal
[2] Univ Coimbra, Ctr New Technol Med, P-3000 Coimbra, Portugal
[3] Univ Coimbra, Assoc Biomed Res & Innovat Light & Image, P-3000 Coimbra, Portugal
[4] Univ Coimbra, Fac Med, Inst Biomed Res Light & Image, P-3000 Coimbra, Portugal
关键词
D O I
10.1001/archopht.120.10.1301
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To compare measurements of retinal thickness in eyes with mild nonproliferative retinopathy in patients with type 2 diabetes mellitus using 2 different techniques: the retinal thickness analyzer (RTA) and optical coherence tomography (OCT). Methods: Twenty-eight eyes from 28 patients with type 2 diabetes mellitus and mild nonproliferative retinopathy were classified according to the Wisconsin grading system by 7-field stereoscopic fundus photography. Ten eyes were classified as level 10 (absence of visible lesions) and 18 as level 20 or 35 (minimal retinopathy). All eyes were examined by the RTA and OCT. Healthy populations were used to establish reference maps for the RTA (n = 14; mean age, 48 years; age range, 42-55 years) and OCT (n = 10; mean age, 56 years; age range, 4368 years). Reference maps were computed using the means + 2 SDs of the values obtained for each location. Increases in thickness were computed as a percentage of increase over these reference maps. Results: The RTA detected increases in thickness in I or more locations in 24 of the 28 diabetic eyes examined, whereas OCT detected increases in only 3 eyes. The percentages of increase detected by the RTA ranged from 0.3% to 73.5%, whereas OCT detected percentages of increase of 0.3% to 4.8%. Conclusion: Optical coherence tomography is less sensitive than the RTA in detecting localized increases in retinal thickness in the initial stages of diabetic retinal disease.
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页码:1301 / 1306
页数:6
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