Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

被引：175

作者：

Dreyfuss, Juliana L. ^{[1
]}

Regatieri, Caio V. ^{[1
,2
]}

Jarrouge, Thais R. ^{[1
]}

Cavalheiro, Renan P. ^{[1
]}

Sampaio, Lucia O. ^{[1
]}

Nader, Helena B. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Disciplina Biol Mol, Dept Bioquim, Rua Tres Maio 100, BR-04044020 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Dept Oftalmol, BR-04023062 Sao Paulo, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2009年 / 81卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

glycosaminoglycans and protein interactions; growth factors; focal adhesion; extracellular matrix; cell cycle; cell proliferation; FIBROBLAST-GROWTH-FACTOR; TGF-BETA; ENDOTHELIAL-CELLS; BINDING DOMAINS; FLAVOBACTERIUM-HEPARINUM; HEPARIN/HEPARAN SULFATE; MITOGENIC ACTIVITY; ACID-RESIDUES; N-SULFATION; MAST-CELLS;

D O I：

10.1590/S0001-37652009000300007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular matrix in all the animal species. This review will focus on the structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling. The heparan sulfate chains due to their vast structural diversity are able to bind and interact with a wide variety of proteins, such as growth factors, chemokines, morphogens, extracellular matrix components, enzymes, among others. There is a specificity directing the interactions of heparan sulfates and target proteins, regarding both the fine structure of the polysaccharide chain as well precise protein motifs. Heparan sulfates play a role in cellular signaling either as receptor or co-receptor for different ligands, and the activation of downstream pathways is related to phosphorylation of different cytosolic proteins either directly or involving cytoskeleton interactions leading to gene regulation. The role of the heparan sulfate proteoglycans in cellular signaling and endocytic uptake pathways is also discussed.

引用

页码：409 / 429

页数：21

共 223 条

[1] Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development [J].