Biomarkers in COPD

被引：50

作者：

Agusti, Alvar ^{[1
,2
]}

Sin, Don D. ^{[3
]}

机构：

[1] Univ Barcelona, IDIBAPS, Hosp Clin, Thorax Inst, E-08036 Barcelona, Spain

[2] CIBER Enfermedades Resp CIBERES, Barcelona 08036, Spain

[3] Univ British Columbia, St Pauls Hosp, James Hogg Res Ctr, Inst Heart & Lung Hlth,Dept Med,Div Resp, Vancouver, BC V6Z 1Y6, Canada

来源：

CLINICS IN CHEST MEDICINE | 2014年 / 35卷 / 01期

关键词：

Chronic bronchitis; Emphysema; Outcomes; Smoking; Treatment; OBSTRUCTIVE PULMONARY-DISEASE; C-REACTIVE PROTEIN; INDIVIDUAL PARTICIPANT METAANALYSIS; GLYCATION END-PRODUCTS; SYSTEMIC INFLAMMATION; ECLIPSE COHORT; CARDIOVASCULAR-DISEASES; ACUTE EXACERBATIONS; SOLUBLE RECEPTOR; CONTROLLED-TRIAL;

D O I：

10.1016/j.ccm.2013.09.006

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Chronic obstructive pulmonary disease (CORD) is a heterogeneous disease that cannot be described by the severity of airflow limitation (forced expiratory volume in the first second of expiration) only. Other measures are needed in clinical practice to assess patients, predict their risk, guide their treatment, and assess their response to it. Over the past few years, there has been a great deal of interest in the identification and validation of biomarkers of potential clinical use in CORD. Here, the authors review some general concepts in the field, discuss currently validated bionnarkers in CORD, and speculate on potential future developments.

引用

页码：131 / +

页数：12

共 48 条

[1] TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial [J].

Aaron, Shawn D. ;

Vandemheen, Katherine L. ;

Maltais, Francois ;

Field, Stephen K. ;

Sin, Don D. ;

Bourbeau, Jean ;

Marciniuk, Darcy D. ;

FitzGerald, J. Mark ;

Nair, Parameswaran ;

Mallick, Ranjeeta .

THORAX, 2013, 68 (02) :142-148

[2] Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype [J].

Agusti, Alvar ;

Edwards, Lisa D. ;

Rennard, Stephen I. ;

MacNee, William ;

Tal-Singer, Ruth ;

Miller, Bruce E. ;

Vestbo, Jorgen ;

Lomas, David A. ;

Calverley, Peter M. A. ;

Wouters, Emiel ;

Crim, Courtney ;

Yates, Julie C. ;

Silverman, Edwin K. ;

Coxson, Harvey O. ;

Bakke, Per ;

Mayer, Ruth J. ;

Celli, Bartolome .

PLOS ONE, 2012, 7 (05)

[3] Addressing the Complexity of Chronic Obstructive Pulmonary Disease From Phenotypes and Biomarkers to Scale-Free Networks, Systems Biology, and P4 Medicine [J].

Agusti, Alvar ;

Sobradillo, Patricia ;

Celli, Bartolome .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (09) :1129-1137

[4] Characterisation of COPD heterogeneity in the ECLIPSE cohort [J].

Agusti, Alvar ;

Calverley, Peter M. A. ;

Celli, Bartolome ;

Coxson, Harvey O. ;

Edwards, Lisa D. ;

Lomas, David A. ;

MacNee, William ;

Miller, Bruce E. ;

Rennard, Steve ;

Silverman, Edwin K. ;

Tal-Singer, Ruth ;

Wouters, Emiel ;

Yates, Julie C. ;

Vestbo, Jorgen .

RESPIRATORY RESEARCH, 2010, 11

[5] Blood Eosinophils to Direct Corticosteroid Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease A Randomized Placebo-Controlled Trial [J].

Bafadhel, Mona ;

McKenna, Susan ;

Terry, Sarah ;

Mistry, Vijay ;

Pancholi, Mitesh ;

Venge, Per ;

Lomas, David A. ;

Barer, Michael R. ;

Johnston, Sebastian L. ;

Pavord, Ian D. ;

Brightling, Christopher E. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (01) :48-55

[6] Network medicine: a network-based approach to human disease [J].

Barabasi, Albert-Laszlo ;

Gulbahce, Natali ;

Loscalzo, Joseph .

NATURE REVIEWS GENETICS, 2011, 12 (01) :56-68

[7] Serum amyloid A is a biomarker of acute exacerbations of chronic obstructive pulmonary disease [J].

Bozinovski, Steven ;

Hutchinson, Anastasia ;

Thompson, Michelle ;

MacGregor, Lochlan ;

Black, James ;

Giannakis, Eleni ;

Karlsson, Anne-Sophie ;

Silvestrini, Roger ;

Smallwood, David ;

Vlahos, Ross ;

Irving, Louis B. ;

Anderson, Gary P. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (03) :269-278

[8] Outcomes for COPD pharmacological trials:: from lung function to biomarkers [J].

Cazzola, M. ;

MacNee, W. ;

Martinez, F. J. ;

Rabe, K. F. ;

Franciosi, L. G. ;

Barnes, P. J. ;

Brusasco, V. ;

Burge, P. S. ;

Calverley, P. M. A. ;

Celli, B. R. ;

Jones, P. W. ;

Mahler, D. A. ;

Make, B. ;

Miravitlles, M. ;

Page, C. P. ;

Palange, P. ;

Parr, D. ;

Pistolesi, M. ;

Rennard, S. I. ;

Moelken, M. P. Rutten-Van ;

Stockley, R. ;

Sullivan, S. D. ;

Wedzicha, J. A. ;

Wouters, E. F. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 31 (02) :416-468

[9] Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary Disease [J].

Celli, Bartolome R. ;

Locantore, Nicholas ;

Yates, Julie ;

Tal-Singer, Ruth ;

Miller, Bruce E. ;

Bakke, Per ;

Calverley, Peter ;

Coxson, Harvey ;

Crim, Courtney ;

Edwards, Lisa D. ;

Lomas, David A. ;

Duvoix, Annelyse ;

MacNee, William ;

Rennard, Stephen ;

Silverman, Edwin ;

Vestbo, Jorgen ;

Wouters, Emiel ;

Agusti, Alvar .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 185 (10) :1065-1072

[10] The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease [J].

Celli, BR ;

Cote, CG ;

Marin, JM ;

Casanova, C ;

de Oca, MM ;

Mendez, RA ;

Pinto Plata, V ;

Cabral, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (10) :1005-1012

← 1 2 3 4 5 →