Hepatitis C Virus Current and Evolving Treatments for Genotypes 2 and 3

被引：16

作者：

Ampuero, Javier

Romero-Gomez, Manuel ^{[1
]}

机构：

[1] Virgen Macarena Virgen Rocio Univ Hosp, Unit Clin Management Digest Dis, Seville 41017, Spain

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2015年 / 44卷 / 04期

关键词：

Hepatitis C; Genotype; 2; 3; Direct-acting antiviral; Sustained virologic response; DACLATASVIR PLUS SOFOSBUVIR; COST-EFFECTIVENESS; RIBAVIRIN; PEGINTERFERON; STEATOSIS; INFECTION; THERAPY; COMBINATION; INHIBITOR; REGIMENS;

D O I：

10.1016/j.gtc.2015.07.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Hepatitis C virus (HCV) genotypes 2 and 3 have previously been classified as easy-to-treat genotypes, because sustained virologic responses (SVRs) up to 80% have been achieved with 24-week peginterferon and ribavirin. More detailed studies have shown differences between HCV genotypes 2 and 3, indicating that genotype 3 has become the most difficult-to-treat genotype. With new drugs, new challenges are emerging regarding relapse rates, the role of ribavirin, and optimal duration of therapy. Sofosbuvir remains the backbone of genotype 3 therapy, whereas this drug is not an option in patients with creatinine clearance lower than 30 mL/min.

引用

页码：845 / +

页数：14

共 41 条

[1]

Sofosbuvir in the Treatment of Chronic Hepatitis C: New Dog, New Tricks [J].

Abraham, George M. ;

Spooner, Linda M. .

CLINICAL INFECTIOUS DISEASES, 2014, 59 (03) :411-415

[2]

Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection [J].

Ampuero, J. ;

del Campo, J. A. ;

Rojas, L. ;

Garcia-Lozano, R. J. ;

Buti, M. ;

Sola, R. ;

Forns, X. ;

Moreno-Otero, R. ;

Andrade, R. ;

Diago, M. ;

Salmeron, J. ;

Rodrigo, L. ;

Pons, J. A. ;

Navarro, J. M. ;

Calleja, J. L. ;

Garcia-Samaniego, J. ;

Garcia-Valdecasas, M. ;

Rojas, A. ;

Millan, R. ;

Gonzalez-Escribano, M. F. ;

Romero-Gomez, M. .

GENES AND IMMUNITY, 2015, 16 (05) :297-300

[3]

Review article: HCV genotype 3 - the new treatment challenge [J].

Ampuero, J. ;

Romero-Gomez, M. ;

Reddy, K. R. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2014, 39 (07) :686-698

[4]

PNPLA3 rs738409 causes steatosis according to viral & IL28B genotypes in hepatitis C [J].

Ampuero, Javier ;

Del Campo, Jose A. ;

Rojas, Lourdes ;

Garcia-Lozano, Jose R. ;

Sola, Ricard ;

Andrade, Raul ;

Pons, Jose A. ;

Navarro, Jose M. ;

Calleja, Jose L. ;

Buti, Maria ;

Gonzalez-Escribano, Maria F. ;

Forns, Xavier ;

Diago, Moises ;

Garcia-Samaniego, Javier ;

Romero-Gomez, Manuel .

ANNALS OF HEPATOLOGY, 2014, 13 (04) :356-363

[5]

[Anonymous], HARV LED SOF PRESCR

[6]

Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C [J].

Bochud, Pierre-Yves ;

Cai, Tao ;

Overbeck, Kathrin ;

Bochud, Murielle ;

Dufours, Jean-Francois ;

Muellhaupt, Beat ;

Borovicka, Jan ;

Heim, Markus ;

Moradpour, Darius ;

Cerny, Andreas ;

Malinverni, Raffaele ;

Francioli, Patrick ;

Negro, Francesco .

JOURNAL OF HEPATOLOGY, 2009, 51 (04) :655-666

[7]

Epidemiological changes in hepatitis C virus genotypes in France:: evidence in intravenous drug users [J].

Bourlière, M ;

Barberin, JM ;

Rotily, M ;

Guagliardo, V ;

Portal, I ;

Lecomte, L ;

Benali, S ;

Boustière, C ;

Perrier, H ;

Jullien, M ;

Lambot, G ;

Loyer, R ;

LeBars, O ;

Daniel, R ;

Khiri, H ;

Halfon, P .

JOURNAL OF VIRAL HEPATITIS, 2002, 9 (01) :62-70

[8]

Optimal therapy of genotype-2 chronic hepatitis C: what's new? [J].

Bourliere, Marc ;

Benali, Souad ;

Ansaldi, Christelle ;

Le Folgoc, Gaelle ;

Riso, Aurelie ;

Lecomte, Laurence .

LIVER INTERNATIONAL, 2015, 35 :21-26

[9]

Daclatasvir Plus Peginterferon and Ribavirin Is Noninferior to Peginterferon and Ribavirin Alone, and Reduces the Duration of Treatment for HCV Genotype 2 or 3 Infection [J].

Dore, Gregory J. ;

Lawitz, Eric ;

Hezode, Christophe ;

Shafran, Stephen D. ;

Ramji, Alnoor ;

Tatum, Harvey A. ;

Taliani, Gloria ;

Tran, Albert ;

Brunetto, Maurizia R. ;

Zaltron, Serena ;

Strasser, Simone I. ;

Weis, Nina ;

Ghesquiere, Wayne ;

Lee, Samuel S. ;

Larrey, Dominique ;

Pol, Stanislas ;

Harley, Hugh ;

George, Jacob ;

Fung, Scott K. ;

de Ledinghen, Victor ;

Hagens, Peggy ;

McPhee, Fiona ;

Hernandez, Dennis ;

Cohen, David ;

Cooney, Elizabeth ;

Noviello, Stephanie ;

Hughes, Eric A. .

GASTROENTEROLOGY, 2015, 148 (02) :355-U147

[10]

IFNL3 polymorphisms predict response to therapy in chronic hepatitis C genotype 2/3 infection [J].

Eslam, Mohammed ;

Leung, Reynold ;

Romero-Gomez, Manuel ;

Mangia, Alessandra ;

Irving, William L. ;

Sheridan, David ;

Spengler, Ulrich ;

Mollison, Lindsay ;

Cheng, Wendy ;

Bugianesi, Elisabetta ;

McLeod, Duncan ;

Zaitoun, Abed M. ;

Attino, Vito ;

Goeltz, Diane ;

Nattermann, Jacob ;

Douglas, Mark ;

Booth, David R. ;

Georget, Jacob ;

Ahlenstiel, Gobo .

JOURNAL OF HEPATOLOGY, 2014, 61 (02) :235-241

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