Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo

被引：74

作者：

Jiang, Baohong ^{[1
]}

Zhang, Lin ^{[1
]}

Wang, Yingchun ^{[1
]}

Li, Ming ^{[1
]}

Wu, Wanying ^{[1
]}

Guan, Shuhong ^{[1
]}

Liu, Xuan ^{[1
]}

Yang, Min ^{[1
]}

Wang, Junchen ^{[2
]}

Guo, De-an ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China

[2] Tongji Univ, Dept Pathol, Dongfang Hosp, Shanghai 200120, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 07期

关键词：

Doxorubicin; Tanshinone IIA sodium sulfonate; Cardiomyopathy; RAT CARDIAC-CELLS; SALVIA-MILTIORRHIZA; OXIDATIVE STRESS; MICE; CARDIOMYOPATHY; HYPERTROPHY; SUPPRESSION; APOPTOSIS; DAMAGE; MODEL;

D O I：

10.1016/j.fct.2009.03.038

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone HA sodium sulfonate (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity. In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore. the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone. These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1538 / 1544

页数：7

共 24 条

[1]

Tomato-oleoresin supplement prevents doxorubicin-induced cardiac myocyte oxidative DNA damage in rats [J].