Three-dimensional proton spectroscopy of deep gray matter nuclei in relapsing-remitting MS

被引：54

作者：

Inglese, M ^{[1
]}

Liu, S ^{[1
]}

Babb, JS ^{[1
]}

Mannon, LJ ^{[1
]}

Grossman, RI ^{[1
]}

Gonen, O ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA

来源：

NEUROLOGY | 2004年 / 63卷 / 01期

关键词：

D O I：

10.1212/01.WNL.0000133133.77952.7C

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The metabolic changes in the deep gray matter (GM) nuclei, thalamus, and basal ganglia of patients with relapsing-remitting multiple sclerosis were investigated with quantitative, multivoxel, three-dimensional proton MR spectroscopy. This technique facilitated the study of several bilateral structures in a single session at sub-cubic centimeter spatial resolution. Compared with 9 matched control subjects, the deep GM nuclei of 11 patients showed 7% lower N-acetylaspartate and 14% higher choline levels (p = 0.02 for both).

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页码：170 / 172

页数：3

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