Structural studies of cytotoxic marine alkaloids: Synthesis of novel ring-E analogues of ascididemin and their in vitro and in vivo biological evaluation

被引：25

作者：

Lindsay, BS ^{[1
]}

Christiansen, HC ^{[1
]}

Copp, BR ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

来源：

TETRAHEDRON | 2000年 / 56卷 / 03期

关键词：

marine metabolites; structure-activity; antitumour compounds; alkaloids;

D O I：

10.1016/S0040-4020(99)01038-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cytotoxic marine alkaloid ascididemin and various pyridine ring-E analogues have been synthesised in an attempt to determine the pharmaceutical utility and structure-activity requirements for the parent alkaloid. All compounds synthesised were evaluated in a wide range of biological screens for selective cytotoxicity, antiviral, antifungal and antimicrobial properties. Many analogues exhibited selective cytotoxicity to human solid tumour cell-lines in vitro, with one also exhibiting moderate antitumour activity in in vivo xenograft assays. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：497 / 505

页数：9

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