A Single Bicontinuous Cubic Phase Induced by Fusion Peptides

被引：44

作者：

Fuhrmans, Marc ^{[1
,2
]}

Knecht, Volker ^{[3
]}

Marrink, Siewert J. ^{[1
,2
]}

机构：

[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, NL-9747 AG Groningen, Netherlands

[2] Univ Groningen, Zernike Inst Adv Mat, NL-9747 AG Groningen, Netherlands

[3] Max Planck Inst Colloids & Interfaces, Dept Theory & Biosyst, D-14424 Potsdam, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 26期

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; MEMBRANE-FUSION; INFLUENZA HEMAGGLUTININ; VESICLE FUSION; FORCE-FIELD; CURVATURE; MECHANISM; BILAYERS; LIPIDS; MODEL;

D O I：

10.1021/ja903224q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a bicontinuous cubic phase forming in the presence of the Influenza HA fusion peptide in coarse grained molecular dynamics simulations. Starting from a random mixture of DOPE, water, and fusion peptides, we observe spontaneous formation of a stable bicontinuous phase. Unlike all previously reported bicontinuous cubic phases the one formed in our simulations is a single phase in the sense that there are no multiple isolated compartments of water or lipid.

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页码：9166 / +

页数：3

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