Huntingtin fragments that aggregate go their separate ways

被引：19

作者：

DiFiglia, M ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02114 USA

来源：

MOLECULAR CELL | 2002年 / 10卷 / 02期

关键词：

D O I：

10.1016/S1097-2765(02)00609-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-terminal region of mutant huntingtin forms intranuclear and cytoplasmic aggregates in neurons that may contribute to neuronal death in Huntington's disease. Lunkes et al. (2002) show that different endoprotease-cleaved huntingtin fragments form nuclear and cytoplasmic inclusions.

引用

页码：224 / 225

页数：2

共 11 条

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