Subcellular localization of the alpha(7) nicotinic receptor in rat cerebellar granule cell layer

被引：36

作者：

Caruncho, HJ

Guidotti, A

Lindstrom, J

Costa, E

Pesold, C

机构：

[1] UNIV ILLINOIS,INST PSYCHIAT,CHICAGO,IL 60612

[2] UNIV SANTIAGO DE COMPOSTELA,SCH MED,DEPT MORPHOL SCI,SANTIAGO COMPOSTE 15705,SPAIN

[3] UNIV PENN,SCH MED,DEPT NEUROSCI,PHILADELPHIA,PA 19104

来源：

NEUROREPORT | 1997年 / 8卷 / 06期

关键词：

alpha(7) subunit; cerebellum; glomeruli; granule cell layer; nicotine receptor; Purkinje cell layer;

D O I：

10.1097/00001756-199704140-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of the alpha(7) nicotinic receptor subunit in the rat cerebellum was studied immunohistochemically at the electron microscope level using an alpha(7) subunit-specific antibody. The granule cell layer showed a much lower level of immunoreactivity for the alpha(7) subunit than the Purkinje cell layer. Granule cell somata were completely devoid of labeling; this appeared to be restricted to glomeruli exclusively located in the membranes of granule cell dendrites. The alpha(7) immunolabeling was located not at active synaptic areas but was mostly perisynaptic. This localization suggests that nicotinic receptors containing the alpha(7) subunit could have a modulatory function and/or play a direct role in the generation of synaptic currents.

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收藏

页码：1431 / 1433

页数：3

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