Trafficking of matrix collagens through bone-resorbing osteoclasts

被引：295

作者：

Nesbitt, SA

Horton, MA

机构：

[1] Department of Medicine, Univ. College of London Med. School, University College London

来源：

SCIENCE | 1997年 / 276卷 / 5310期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.276.5310.266

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An intracellular pathway for proteins liberated from mineralized matrix during resorption was identified in osteoclasts. Analysis by confocal microscopy of sites of active bone resorption showed that released matrix proteins, including degraded type I collagen, were endocytosed along the ruffled border within the resorption compartment and transcytosed through the osteoclast to the base lateral membrane. Intracellular trafficking of degraded collagen, as typified by the resorbing osteoclast, may provide the cell with a regulatory mechanism for the control of tissue degradation.

引用

页码：266 / 269

页数：4

共 22 条

[1] POLARIZED SECRETION OF LYSOSOMAL-ENZYMES - CO-DISTRIBUTION OF CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTORS AND LYSOSOMAL-ENZYMES ALONG THE OSTEOCLAST EXOCYTIC PATHWAY [J].