Kinases conquer the inflammasomes

被引：16

作者：

Neumann, Konstantin ^{[1
]}

Ruland, Juergen ^{[1
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Klin Chem & Pathobiochem, D-80290 Munich, Germany

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 12期

关键词：

TYROSINE KINASE; ACTIVATION; INHIBITOR;

D O I：

10.1038/ni.2763

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammasomes are signaling platforms of the innate immune system that activate proinflammatory cytokines after microbial pathogens are sensed or sterile danger is detected. The kinases Syk and Jnk control inflammasome activation by mediating phosphorylation of the inflammasome adaptor ASC.

引用

页码：1207 / 1208

页数：3

共 12 条

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