Unnatural natural triterpenes produced by altering isoleucine into alanine at position 261 in hopene synthase and the importance of having the appropriate bulk size at this position for directing the stereochemical destiny during the polycyclization cascade

被引：40

作者：

Hoshino, T ^{[1
]}

Abe, T

Kouda, M

机构：

[1] Niigata Univ, Fac Agr, Dept Appl Biol Chem, Niigata 9502181, Japan

[2] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 06期

关键词：

D O I：

10.1039/b000711k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubation of squalene with the site-directed mutant of Ile261Ala of squalene-hopene cyclase from Alicyclobacillus acidocaldarius afforded multiple triterpenes consisting of tri-, tetra- and penta-cyclic skeletons, together with a final product of hopene, among which the previously unknown 6/6/6/6-fused tetracyclic skeletal compounds, denoted prohopene A and B, are included.

引用

页码：441 / 442

页数：2

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