Autophagy in bone: Self-eating to stay in balance

被引：136

作者：

Pierrefite-Carle, Valerie ^{[1
]}

Santucci-Darmanin, Sabine ^{[1
]}

Breuil, Veronique ^{[1
,2
]}

Camuzard, Olivier ^{[1
,3
]}

Carle, Georges F. ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, Fac Med, UMR E TIRO MATOs CEA 4320, iBEB, F-06189 Nice, France

[2] CHU Nice, Serv Rhumatol, F-06202 Nice, France

[3] CHU Nice, Serv Chirurg Reparatrice & Main, F-06202 Nice, France

来源：

AGEING RESEARCH REVIEWS | 2015年 / 24卷

关键词：

Autophagy; Bone; Osteoporosis; MESENCHYMAL STEM-CELLS; ANTIDIABETIC DRUG METFORMIN; INTRACELLULAR CALCIUM-PHOSPHATE; VITAMIN-D3 INDUCES AUTOPHAGY; GENOME-WIDE ASSOCIATION; OSTEOCLAST-LIKE CELLS; KAPPA-B LIGAND; OXIDATIVE STRESS; UNCONVENTIONAL SECRETION; PAGETS-DISEASE;

D O I：

10.1016/j.arr.2015.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight the autophagy role in the different bone cell types, i.e., osteoblasts, osteoclasts and osteocytes. We also discuss the effects of autophagy modulators in bone physiology and of bone anabolic compounds in autophagy. Finally, we analyzed studies regarding bone cell autophagy-deficient mouse models to obtain a more general view on how autophagy modulates bone physiology and pathophysiology, particularly during aging. (C) 2015 Elsevier B.V. All rights reserved.

引用

收藏

页码：206 / 217

页数：12

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