California ground squirrel (Spermophilus beecheyi) blood sera inhibits crotalid venom proteolytic activity

被引：27

作者：

Biardi, JE

Coss, RG ^{[1
]}

Smith, DG

机构：

[1] Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA

[2] Univ Calif Davis, Grad Grp Ecol, Davis, CA 95616 USA

[3] Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA

来源：

TOXICON | 2000年 / 38卷 / 05期

关键词：

D O I：

10.1016/S0041-0101(99)00179-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some California ground squirrels (Spermophilus beecheyi) show limited necrosis following envenomation by northern Pacific rattlesnakes (Crotalus viridis oreganus). This study demonstrates that S. beecheyi blood sera inhibits venom proteases. Sera from rattlesnake-abundant habitats inhibited C. v. oreganus venom more effectively than venom from two allopatric rattlesnake species, C. v. viridis and C, atrox, suggesting evolutionary specialization. The pattern of inhibition among squirrel populations corresponds best with history of rattlesnake predation, in contrast to current rattlesnake density. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：713 / 721

页数：9

共 25 条

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